Trichotillomania is more common in children who have anxiety, and it can also lead to more anxiety from the social isolation and bullying that result from hair loss. It is a vicious circle where the self-inflicted hair loss is in itself distressing, but that distress leads to more pulling. You can see from the following picture that cutting hair short is not an effective treatment. Skin picking and nail biting are similar body focused repetitive behaviors (BFRB).
Do dietary changes help?
What help is available?
Are there supplements that help?
I've been recommending NAC for awhile now for trichotillomania (as well as nail biting and OCD) and have had mixed response, but overall positive. For those who did not find it helpful, I suspect they did not use it long enough since it can take over a month to see benefit. I think parents like the fact that it is a supplement, which is easier to provide than behavioral therapy, but therapy is still an important part of the treatment. Those who have the best results do therapy along with the supplement.
How long does it take to see results with NAC?
It takes about a month or two (studies show 4-9 weeks) of NAC to show benefit. Taking a supplement for that length of time without benefit can be difficult and might cause some to quit prematurely, but I'd recommend at least two months before deciding it doesn't work. Talk with your child's doctor before starting any supplement and before stopping it.
How much NAC do you give?
Most studies have been done in adults, so the best pediatric dose is not known. For adults and children over about 45 pounds, 600 - 2400 mg has been studied, but no ideal dose is known. It has been suggested about 60mg/kg/day for younger children, but there is no standard dose.
It may also be difficult to give to a child who cannot swallow the capsules. While in theory the capsule could be opened (and the powder is available in bulk), the taste and smell is of rotten eggs, so I cannot imagine a child taking it mixed in food or drink. Tips on teaching kids to swallow pills is covered here.
Talk with your child's pediatrician before beginning any supplement, even though they are sold over the counter. This helps your child's doctor know more about what is going on, what works and what doesn't for your child, and to help monitor for possible reactions if they are known (especially if your child is on prescription medicines).
One dosing strategy for children over 45 pounds is to give a 600 mg capsule twice per day (1200 mg) for a week and increasing to 2 capsules twice per day (2400 mg) after 4 weeks if needed. I have also seen titration methods, beginning with one capsule daily for the first week (600mg), then one capsule twice a day for the 2nd week (1200mg), then 3 capsules divided in 2 unequal doses (1800 mg) for the 3rd week and 4 capsules divided in 2 doses (2 capsules twice per day = 2400 mg) thereafter.
Is NAC safe with other medicines?
NAC might interact with other medicines, so it is recommended to discuss interactions with your doctor and pharmacist. Since antidepressants are often used in anxiety disorders such as trichotillomania, I have tried to see what interactions might be known. Research has shown that rats need lower doses of imipramine (a tricyclic antidepressant I don't use in kids) and escitalopram (Lexapro, an SSRI antidepressant) when taking NAC, but NAC doesn't affect the dose of desipramine (another tricyclic antidepressant) and bupropion (Wellbutrin). In contrast, NAC in the rats actually made fluoxetine (prozac) less effective, so higher doses were needed. Obviously people are not rats, and this is an area that needs to be further studied, but if your child is on any prescription medicines, be sure your doctor and pharmacist know that he is starting NAC.
If anyone knows of human studies or more information, please post in the comments below!
How long will NAC be needed?
It is thought that NAC is safe long term and might be needed long term since the underlying anxiety does not go away, only the symptoms are controlled with the NAC. This is an important reason to do the therapy too, since learning techniques to identify and appropriately deal with stressors can help life long without side effects. When NAC is stopped, symptoms might return. I will often suggest a trial off NAC once all habits being treated have been gone for at least a month. Weaning to a lesser dose for a few weeks is one way to test without going completely off, and I find many families feel more comfortable with a wean versus sudden stopping. If symptoms resume, restart the NAC. (Note: This is my own version of what to do -- I have not found guidance in the studies I've read. If anyone knows anything more specific, please comment below so we can all learn!) I did see one case report of a person treated for 6 months with NAC and the symptoms did not return for a full month after stopping NAC.
Is NAC safe?Side effects are rare, but may include gastrointestinal upset, diarrhea, nausea, rash, vomiting and fatigue. One study of AIDS patients used 8000 mg of NAC per day, showing overall safety at high doses. This is NOT the dose recommended for hair pulling, skin picking, and most psychiatric and neurologic disorders. Some studies suggest kidney stones are more common at higher doses, but taking high doses of Vitamin C at the same time as each NAC dose can help prevent kidney stones from forming. A supplement of Vitamin B6 has also been recommended by some because NAC increases the body's use of Vitamin B6, but most children can get plenty of this vitamin from a healthy diet. Many foods are rich in B6, including fish, beef, poultry, fruits (not citrus fruits), vegetables, and grains. Vitamin B6 is also in most multivitamins, so if you choose to supplement, a standard multivitamin would be considered safe. Talk with your child's doctor if you plan on doing mega doses of vitamins, as that can sometimes be harmful.
What else is NAC used for?
When I was a pediatric resident, we used NAC for acetaminophen (Tylenol) overdoses. I hadn't thought of it for many years, then a few years ago I started to hear of it being used for other things. Research for using NAC for a variety of psychiatric and neurologic disorders in addition to trichotillomania is promising. There is evidence that NAC works for some symptoms involved with autism, Alzheimer's disease, cocaine and cannabis (marijuana) addiction, bipolar disorder, depression, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. Disorders such as anxiety, attention deficit hyperactivity disorder and mild traumatic brain injury also have preliminary studies supporting NAC use but require larger confirmatory studies.
Update 11-3-17: I just heard of an effervescent tablet that gets good reviews from specialists. PharmaNac has 900 mg per tablet, and their website recommends 2-4 tablets per day. Note: Their website mentions a potential issue with some antibiotics and NAC, but those claims have been disputed. It would not be wrong to separate dosing of antibiotic and NAC, but it might not be an issue.
For More Information:
For more information, see Experts Consensus Treatment Guidelines for Trichotillomania and Skin Picking and the many other resources found on The TLC Foundation for Body-Focused Repetitive Behaviors.
KidsHealth has a Trichotillomania page for teens.